Health Care

Glutathione and the Phases of Detoxification

The human body has many ways of dealing with all the various types of toxins which attack it on a daily basis, but of these the master antioxidant “Glutathione” is the most important detoxification system of them all. For efficient detoxification to happen a series of reactions must occur which binds toxins and eliminates them from the body.

Glutathione and the Liver

Every cell in the human body utilizes glutathione due to its unsurpassed antioxidant function and its ability to prevent proliferation of destructive free radicals. The liver and kidneys are the bodies primary detoxification organs so it is no surprise that the highest concentration of glutathione (the bodies main detoxification nutrient) is found there.

Phases of Detoxification

There are three phases to the detoxification process:

Phase one – This phase is toxin modification. A toxin will be identified within a cell. Once detected the toxin will be modified via reduction and oxidation reactions so they become a recognisable form the body can target.

Phase two – This phase is toxin conjugation. Following on from phase one the toxins activated metabolites can now be bound with or “conjugated” directly with glutathione. Once this process of conjugation occurs, the harmful metabolites will be disabled and will be prevented from diffusing across cell membranes.

Phase three – This phase is excretion. Following on from phase two. A specific derivative of glutathione comes into play. This is Glutathione S Transferase. These will catalyze reactions within the body. Toxins can now be metabolized and excreted from the body.

To summarise, a toxin is converted into a compound that can be grabbed by glutathione and eliminated from the body via bile or urine.

The Power of Glutathione

The main power behind glutathiones detoxification prowess is achieved mainly from cysteine. This is an amino acid rich in sulfur. Sulfur is a very sticky molecule and as such will act much like flypaper, but in this case the flies are the toxins in your body. A lack of glutathione in our bodies will interrupt the ability for this whole detoxification process to occur. If the detoxification process is impaired, then the result will be an accumulation of toxic elements and compounds in our body and this will unquestionably have a negative effect on our health which can range from mild to fatal.